Systematic Review: Diagnostic Accuracy Of Hpv Dna Test As An Alternative To Visual Inspection With Acetic Acid (Via) For Early Cervical Cancer Screening

Ghitanisa Azzahra; ⁠Qais Maulana Gusti; ⁠Shafira Nova Apsari

doi:10.55227/ijhet.v4i4.463

Authors

Ghitanisa Azzahra Universitas Pertahanan Republik Indonesia
⁠Qais Maulana Gusti Universitas Pertahanan Republik Indonesia
⁠Shafira Nova Apsari niversitas Pertahanan Republik Indonesia

DOI:

https://doi.org/10.55227/ijhet.v4i4.463

Keywords:

Acetic Acid, Cervical Cancer Screening, Diagnostic Accuracy, Human Papillomavirus, HPV DNA Test.

Abstract

Cervical cancer is a major health issue globally, especially in low- and middle-income countries, where early detection is critical to reducing mortality. This systematic review aims to evaluate the diagnostic accuracy of HPV DNA testing compared to Visual Inspection with Acetic Acid (VIA) for early cervical cancer screening. The study reviewed literature published between 2020 and 2025 from multiple databases, selecting studies including women aged 18 and above from diverse settings. Data extraction utilized quality assessment through QUADAS-2 and focused on sensitivity, specificity, and predictive values. Four studies from Kenya, Africa, Italy, and Indonesia were analyzed. Results showed HPV DNA tests consistently demonstrate high sensitivity (94%–98%) and specificity (69%–100%), outperforming VIA in detecting high-risk HPV infections before morphological changes. The review concludes that HPV DNA testing is a promising alternative or complement to VIA, providing earlier and more accurate detection. However, challenges such as cost and resource availability remain. Effective integration strategies tailored to local infrastructure are essential to maximize benefits.

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