Effect of Bungur Leaf Extract on Glucose Reduction in Kidney Dysfunction Rats

Firelza Nabhaki; Indri Meirista; Rahmadha Trifah

doi:10.55227/ijhet.v4i5.513

Authors

Firelza Nabhaki Department of Pharmacy, STIKES Harapan Ibu Jambi, Jambi, Indonesia
Indri Meirista Pharmacy Study Program, STIKes Harapan Ibu Jambi, Indonesia
Rahmadha Trifah Pharmacy Study Program, STIKes Harapan Ibu Jambi, Indonesia

DOI:

https://doi.org/10.55227/ijhet.v4i5.513

Keywords:

Lagerstroemia speciosa, blood glucose, creatinine, nephroprotective, alloxan, Lagerstroema speciosa, blood glucose, creatinine, nephroprotective, alloxan, pioglitazone

Abstract

Diabetes mellitus is a metabolic disorder with an increasing prevalence in Indonesia, including in the city of Jambi. Conventional antidiabetic therapies such as metformin, sulfonylureas, and insulin are effective in lowering glucose levels, but long-term use can cause side effects, including the risk of kidney damage. Bungur leaves (Lagerstroemia speciosa) contain flavonoids, alkaloids, tannins, triterpenoids, and corosolic acid, which have potential antihyperglycemic and nephroprotective properties. This study aimed to evaluate the effects of bungur leaf ethanol extract on blood glucose levels and kidney function in male white rats induced with alloxan and gentamicin. The study was conducted experimentally with seven treatment groups. The parameters observed included blood glucose and serum creatinine levels. The results showed a significant decrease in glucose, with the highest effectiveness at a dose of 1200 mg/kgBW. The extract also lowered creatinine levels, indicating a renal protective effect. These findings suggest the potential of crape myrtle leaves as a herbal antidiabetic agent while maintaining renal function

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References

Alhafizoh, F., Novitasari, R., Yuswantoro, J., Handayani, T. T., Biologi, J., Matematika, F., Ilmu, D., Alam, P., Lampung, U., Soemantri, J., No, B., & Lampung, B. (2022). Efektivitas Daun Bungur (Lagerstroemia speciosa L.) Sebagai Alternatif Penghambat Diabetes Pada Mencit (Mus musculus L.).

Grenvilco, O., Kumontoy, D., Deeng, D., & Mulianti, T. (2023). Pemanfaatan Tanaman Herbal Sebagai Obat Tradisional Untuk Kesehatan Masyarakat Di Desa Guaan Kecamatan Mooat Kabupaten Bolaang Mongondow Timur, 16(3).

Halim Ramadhan, M., Indra Aulia, D., & Azzahra, N. (2025). Uji Efektivitas Daun Bungur (Lagerstroemia speciosa L.) terhadap Penghambatan Transportasi Glukosa Tikus Putih Galur Wistar (Rattus norvegicus). Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran, 3(2), 98–108.

Kien, D. X., Ha, D. V., Kien, P. T., Huy, T. H. A., Nga, N. T., Dung, V. M., Toan, T. D., Anh, N. P., & Ngan, N. H. (2024). Blood Glucose Lowering Effect of Lagerstroemia speciosa L. Leaves Extract on Type 2 Diabetic Rat Model. Tropical Journal of Natural Product Research, 8(7), 7709–7714.

Lestari. (2021). Diabetes Melitus: Review Etiologi.

Mitra, A. D., Arifin, H., & Rivai, H. (2021). The Effect of Captopril on the Decrease of Systolic and Diastolic Blood Pressure in Hypertension Rat with Kidney Dysfunction Complications. International Journal of Pharmaceutical Sciences and Medicine, 6(5), 21–31.

Riyanti, S., MA, S., & E, K. (2021). Potensi Daun Bungur (Lagerstroemia loudonii Teijsm. & Binn.) Yang Gugur Sebagai Penghambat Alfa-Glukosidase. Jurnal Farmasi Udayana, 31.