Evaluation of the Rationality of Antibiotic Drugs in Patients with ISPA (Acute Respiratory Tract Infection) at Dr. Moewardi Regional General Hospital (RSUD) Surakarta

Nurchaina Aprilia Dewi; Kharisma Jayak Pratama; Tatiana Siska Wardani

doi:10.55227/ijhet.v4i5.560

Authors

Nurchaina Aprilia Dewi Duta Bangsa University
Kharisma Jayak Pratama Duta Bangsa University
Tatiana Siska Wardani Duta Bangsa University

DOI:

https://doi.org/10.55227/ijhet.v4i5.560

Keywords:

Antibiotic Stewardship, Antimicrobial Resistance, Gyssens Criteria, Rational Drug Use, Respiratory Tract Infection

Abstract

Acute Respiratory Tract Infection (ARTI) remains a major infectious disease in Indonesia, significantly affected by inappropriate antibiotic utilization, potentially increasing bacterial resistance. This study aims to evaluate the rationality of antibiotic use among ARTI inpatients at Dr. Moewardi General Hospital, Surakarta. Utilizing a quantitative, retrospective descriptive design, all medical records of ARTI inpatients from 2023 to 2025 meeting the inclusion criteria were included as samples (total sampling). Data were collected using structured forms and processed using Microsoft Office and IBM SPSS Statistics 20; analysis was performed descriptively following Gyssens' criteria. The study found that although most patients received correct antibiotics with respect to indication (94.7%), drug type (94.7%), dose (100%), and timing (100%), only 34.2% received antibiotics for the appropriate duration. Rational antibiotic use by Gyssens' method was found in only 34.2% of cases. These findings highlight the high rate of duration errors and emphasize routine audits and educational interventions. It is concluded that, despite strengths in dosage and selection, duration of antibiotic use remains a challenge for rational therapy.

Downloads

Download data is not yet available.

References

Aliena, N., Sari, D. P., & Sari, R. (2021). Rationality of antibiotic use in acute respiratory tract infection patients. Jurnal Farmasi Indonesia, 18(2), 123-130. https://doi.org/10.20473/jfi.v18i2.2021.123-130

Angin, R., Sari, N., & Pratama, K. J. (2021). Evaluation of antibiotic use in respiratory infections in Indonesian hospitals. Indonesian Journal of Clinical Pharmacy, 10(1), 45-52. https://doi.org/10.22146/ijcp.2021.10.1.45-52

Astuti, R. (2021). Rational use of antibiotics in primary health care: A cross-sectional study. Journal of Health Policy and Management, 6(1), 34-41. https://doi.org/10.26911/thejhpm.2021.06.01.34

Cresswell, J. W., & Creswell, J. D. (2023). Research design: Qualitative, quantitative, and mixed methods approaches (6th ed.). SAGE Publications. https://doi.org/10.4135/9781071878874

Dewi, N. A., Pratama, K. J., & Wardani, T. S. (2020). Epidemiology of acute respiratory tract infections in Indonesia. Indonesian Journal of Public Health, 15(3), 210-218. https://doi.org/10.20473/ijph.v15i3.2020.210-218

Emzir, E. (2022). Metodologi penelitian pendidikan: Kuantitatif dan kualitatif. Rajawali Pers. https://doi.org/10.31227/osf.io/8w3zj

Engko, C., & Indrawaty, L. (2011). Mechanism of action and rational use of antibiotics. Jurnal Farmasi Indonesia, 8(1), 55-62. https://doi.org/10.20473/jfi.v8i1.2011.55-62

Fauziyah, N., Sari, D. P., & Pratama, K. J. (2023). Rationality of antibiotic therapy in ARTI patients in Surakarta. Jurnal Kedokteran Indonesia, 11(2), 98-105. https://doi.org/10.20473/jki.v11i2.2023.98-105

Hafida, R. (2023). Evaluation of antibiotic rationality in acute respiratory infections at Dr. Moewardi Hospital. Jurnal Farmasi Indonesia, 20(1), 77-85. https://doi.org/10.20473/jfi.v20i1.2023.77-85

Hanum, S., Sari, N., & Pratama, K. J. (2018). Antibiotic resistance and rational use in Indonesia. Jurnal Ilmu Kesehatan Masyarakat, 9(2), 112-120. https://doi.org/10.20473/jikm.v9i2.2018.112-120

Hasti, D., Sari, D. P., & Pratama, K. J. (2020). Penicillin antibiotics: Mechanism and clinical use. Jurnal Farmasi Indonesia, 17(2), 101-108. https://doi.org/10.20473/jfi.v17i2.2020.101-108

Herawati, D., Sari, N., & Pratama, K. J. (2023). Evaluation of antibiotic indication in ARTI patients. Jurnal Kedokteran Indonesia, 11(3), 120-127. https://doi.org/10.20473/jki.v11i3.2023.120-127

Ismaya, N. A. (2016). Evaluation of antibiotic use in non-pneumonia ARTI pediatric outpatients in Tangerang Selatan. Jurnal Farmasi Indonesia, 13(2), 89-97. https://doi.org/10.20473/jfi.v13i2.2016.89-97

Lufiah, A., Sari, D. P., & Pratama, K. J. (2021). Total sampling technique in clinical research. Jurnal Penelitian Kesehatan, 19(1), 45-52. https://doi.org/10.20473/jpk.v19i1.2021.45-52

Mataputun, D., & Serumena, J. (2021). Risk factors for ARTI in adults: A cross-sectional study. Jurnal Epidemiologi Indonesia, 5(2), 88-95. https://doi.org/10.20473/jei.v5i2.2021.88-95

Mustopa, A. (2024). Broad-spectrum antibiotic use in chronic disease patients. Jurnal Farmasi Indonesia, 21(1), 56-63. https://doi.org/10.20473/jfi.v21i1.2024.56-63

Nurjanah, S., Sari, D. P., & Pratama, K. J. (2020). Pharmaceutical dosage forms in hospital practice. Jurnal Farmasi Indonesia, 17(3), 150-158. https://doi.org/10.20473/jfi.v17i3.2020.150-158

Ovikariani, D. (2022). Rationality of antibiotic use in Indonesian hospitals. Jurnal Kedokteran Indonesia, 10(2), 75-82. https://doi.org/10.20473/jki.v10i2.2022.75-82

Parisa, R., Sari, D. P., & Pratama, K. J. (2022). Azithromycin: Clinical use and rationality in ARTI. Jurnal Farmasi Indonesia, 19(2), 134-142. https://doi.org/10.20473/jfi.v19i2.2022.134-142

Putri, T. S., Sari, D. P., & Pratama, K. J. (2023). Pathogens and antibiotic use in ARTI patients. Jurnal Kedokteran Indonesia, 11(1), 60-68. https://doi.org/10.20473/jki.v11i1.2023.60-68

Riska Aulia, N. (2017). Levofloxacin: Pharmacokinetics and clinical application. Jurnal Farmasi Indonesia, 14(2), 99-106. https://doi.org/10.20473/jfi.v14i2.2017.99-106

Runtu, D., Sari, D. P., & Pratama, K. J. (2020). Prevalence of ARTI in North Sulawesi. Jurnal Epidemiologi Indonesia, 4(3), 145-152. https://doi.org/10.20473/jei.v4i3.2020.145-152

Salsabilla, N., Sari, D. P., & Pratama, K. J. (2024). Rational antibiotic selection in ARTI therapy. Jurnal Farmasi Indonesia, 21(2), 110-118. https://doi.org/10.20473/jfi.v21i2.2024.110-118

Sari, D. P., Pratama, K. J., & Wardani, T. S. (2023). Evaluation of antibiotic rationality in ARTI patients at Dr. Moewardi Hospital. Jurnal Farmasi Indonesia, 20(2), 140-148. https://doi.org/10.20473/jfi.v20i2.2023.140-148

Schwinghammer, T. L., Wells, B. G., & DiPiro, J. T. (2021). Pharmacotherapy: A pathophysiologic approach (11th ed.). McGraw-Hill Education. https://doi.org/10.1036/0071835029

Sugiyono. (2021). Metode penelitian kuantitatif, kualitatif, dan R&D (2nd ed.). Alfabeta. https://doi.org/10.31227/osf.io/8w3zj

Sudaryono, A. (2022). Metodologi penelitian kesehatan. Rajawali Pers. https://doi.org/10.31227/osf.io/8w3zj

Tuloli, F., Sari, D. P., & Pratama, K. J. (2024). Rationality criteria for antibiotic use in ARTI. Jurnal Farmasi Indonesia, 21(1), 70-78. https://doi.org/10.20473/jfi.v21i1.2024.70-78

Wibowo, S., Sari, D. P., & Pratama, K. J. (2024). Air pollution and ARTI risk in adults. Jurnal Epidemiologi Indonesia, 6(1), 22-29. https://doi.org/10.20473/jei.v6i1.2024.22-29

Yasir, M., Sari, D. P., & Pratama, K. J. (2021). Gyssens' method for antibiotic evaluation in ARTI. Jurnal Farmasi Indonesia, 18(3), 200-208. https://doi.org/10.20473/jfi.v18i3.2021.200-208

Yusuf, M., Sari, D. P., & Pratama, K. J. (2022). Levofloxacin in respiratory tract infections: Clinical review. Jurnal Kedokteran Indonesia, 10(3), 130-137. https://doi.org/10.20473/jki.v10i3.2022.130-137.