D-Dimer In Pregnancy

Danny Ernest Jonas Luhulima; Batara Imanuel Sirait

doi:10.55227/ijhet.v4i6.696

Authors

Danny Ernest Jonas Luhulima Department of Clinical Pathology, Medical Faculty, Universitas Kristen Indonesia, Indonesia
Batara Imanuel Sirait Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia

DOI:

https://doi.org/10.55227/ijhet.v4i6.696

Keywords:

D-Dimer, Pregnancy, Preeclampsia, Coagulation

Abstract

D-dimer is a fibrin degradation product that serves as a vital biomarker in the fibrinolytic system. This review aims to examine the role and mechanism of D-dimer during pregnancy and its measurement methods. The method used is a literature review of clinical studies and references related to hemostasis in pregnancy. Results show that pregnancy physiologically increases coagulation activity as a natural mechanism to prevent hemorrhage during delivery. Increased D-dimer levels are found in 27% of first-trimester pregnancies, 87% in the second trimester, and 100% in the third trimester. Pathological conditions such as preeclampsia, eclampsia, and venous thromboembolism (VTE) risks are closely linked to significant surges in D-dimer levels. While ELISA remains the gold standard for D-dimer testing, immunoturbidimetric and immunofiltration methods are more commonly used due to their speed and efficiency. In conclusion, although D-dimer levels naturally rise during pregnancy, monitoring this parameter is crucial for predicting medical emergencies like disseminated intravascular coagulation (DIC) to reduce maternal mortality rates.

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