Systematic Literature Review: The Effect Of Different Binders On Paracetamol Tablets
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This study aims to examine the effect of different binders on the physical quality of paracetamol tablets using the Systematic Literature Review (SLR) method. Paracetamol tablets are one of the preparations widely used as analgesics and antipyretics, so the choice of binder plays an important role in determining tablet quality, such as hardness, friability, disintegration time, dissolution, and physical and chemical stability. The method used is a literature study of various studies related to variations in binders in paracetamol tablet formulations and evaluation of their physical quality. The results of the study indicate that the type and concentration of binders have a significant effect on tablet characteristics. Binders such as PVP, gelatin, kawista pectin, konjac glucomannan, durian seed starch, cassava starch, pregelatinized corn starch phosphate, and various other natural starches show different effects on tablet hardness, friability, disintegration time, and dissolution. Natural binders such as pectin and modified starch show the most optimal results because they are able to produce tablets with good physical quality while maintaining optimal drug release. While synthetic binders such as PVP and gelatin provide strong binding strength and improve tablet stability, their use in high concentrations can prolong disintegration time and decrease dissolution. Overall, selecting the right binder is crucial for producing paracetamol tablets that meet pharmacopoeial requirements and provide optimal therapeutic efficacy.
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References
Alphons GJ Voragen, Gerd-jan Coenen, Rene P. Verhoef. (2009). Henk a Schols, Pectin, a versatile polysaccharide present in plant cell walls, structural chemistry, 20: 263-275.
Aulton, M.E., & Taylor, K. (Eds.). (2013). Aulton's pharmaceuticals: the design and manufacture of medicines. Elsevier Health Sciences.
Cahyani, AN, Susanto, A., Dewi, IR, & Nurhikmah, I. (2023). Formulation of paracetamol tablets with a combination of PVP and porang tuber starch (Amorphopallus onchopyllus) as a binding agent on the physical properties of tablets. Jurnal Ilmiah JOPHUS: Journal of Pharmacy UMUS, 4(02), 1-11.
Compart, J., Singh, A., Fettke, J., and Apriyanto, A. (2023). Customizing starch properties: A review of starch modifications and their applications. Polymers (Basel), vol. 15, no. 16, pp. 3491.A Review of Starch Modifications and Their Applications - MDPI
Estrada-Monje A, Alonso-Romero S, Zitzumbo-Guzmán R, Estrada-Moreno IA, Zaragoza-Contreras EA. (2021). Thermoplastic starch-based blends with improved thermal and thermomechanical properties. Polymers, 13(23): 4263.https://doi.org/10.3390/polym13234263
Fegade, V. C., Narkhede, S. B., & Kumar, R. (2023). Formulation and Evaluation of Paracetamol Tablet to Assess Binding Property of Limonia Acidissima Pectin. Tropical Journal of Pharmaceutical and Life Sciences, 10(5), 01-11.
Handayani, T., Aziz, Y, S., & Herlinasari, D. (2020). Production and Quality Testing of Porang (Amorphophallus Oncophyllus Prain) Tuber Flour in Ngrayun District. Journal of Pharmacy and Health 9(1), 13– 22.https://doi.org/10.48191/medfarm.v9i1.27
Khairnar, R.G., Darade, A.R., & Tasgaonkar, R.R. (2024). A review on tablet binders as a pharmaceutical excipient. World Journal of Biology Pharmacy and Health Sciences, 17(3), 295-302.https://doi.org/10.30574/wjbphs.2024
Kosasih, K., Mayasari, M., & Gusmayadi, I. (2025). Development of Paracetamol Tablet Formulations Using Phosphate-Pregelatinized Cornstarch as Binders. International Journal of Medical and Pharmaceutical Research, 6, 581-592.
Krushnakant, DJ (2024). Formulation and evaluation of paracetamol tablets using natural binders. International Journal of Pharmacy and Pharmaceutical Science, 6(1): 137-143.https://doi.org/10.33545/26647222.2024.v6.i1b.112
Kulkarni, V.M., Babare, S.B., Joshi, S.K., Walode, S.G., Rudrapal, M., Kakade, A.P., & Chatur, V.M. (2022). Formulation and Evaluation of Paracetamol Tablets using Coconut Oil as a Binder. Journal of Drug Delivery and Therapeutics, 12, 4-7.
Kumereshwaran, D.D., & Rahman, S.A. (2024). Formulation and Evaluation of Paracetamol Tablets Using Konjac Glucomannan as Natural Halal Binder. Asian Journal of Research in Medical and Pharmaceutical Sciences, 13(4), 110-117.https://doi.org/10.9734/ajrimps/2024/v13i4278
Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. Philadelphia: Lea & Febiger; 1976.
Lestari, ABS, & Eliana, R. (2024). Reworking potential of Cassava starch as a binder in the production of paracetamol tablets using wet granulation method. Journal of Research in Pharmacy, 29(5), 1918-1929.https://doi.org/10.12991/jrespharm.1763611
Lestari, ABS, & Okana, LDAM (2025). Reworking Potential of Polyvinylpyrrolidone K-25 as a Binder in the Production of Paracetamol Tablets. Journal of Fundamental and Applied Pharmaceutical Science, 1, 1.https://doi.org/10.18196/jfaps.v6i1.27034
Pockle, RD, Masareddy, RS, Patil, AS, & Patil, PD (2023). A comprehensive review on pharmaceutical excipients. Therapeutic delivery, 14(7), 443-458.
Putra, DJS (2019). Use of Polyvinyl Pyrolidone (PVP) as a Binder in Betel Leaf Extract Tablet Formulation (Piper betle L.). Udayana Pharmaceutical Journal, 8(1), 14.
Sarkar, S., Chowdhury, S., Chettri, S., Rai, S., Das, S., & Das, S. (2022). Comparative study of different binder concentrations of aloe as natural binder in the preparation of paracetamol tablets. Universal Journal of Pharmaceutical Sciences and Research, 8(2), 19-21.
Shekhara Naik R et al. (2023). A review on banana flower: Nutritional composition, processed products and health benefits. IP Journal of Nutrition, Metabolism and Health Science, 6(3), 110–115.https://doi.org/10.18231/j.ijnmhs.2023.019
Sinaga, A., Auliafendri, N., & Sabina, F. (2025). Preformulation: Concentration of Singali-Ngali Banana Fruit Starch (Musa acuminata Lady Finger) as a Binder for Paracetamol Tablets Using Wet Granulation Method that Meets Pharmacopoeia Requirements. JIFI (Imelda Scientific Journal of Pharmacy), 8(2), 122-128.
Singh, P., Mishra, G., & Dinda, S.C. (2021). Natural excipients in pharmaceutical formulations. In Evidence based validation of traditional medicines: a comprehensive approach (pp. 829-869). Singapore: Springer Singapore.
Sipatu, YS, & Ani, N. (2023). Paracetamol Tablet Formulation using Durian Seed Starch (Durio zibethinus Murr) as a Binding Material by Direct Compression. Journal of Science and Health, 5(5), 568-575.
Wijayanto, A., & Herdianty, J. (2021). Formulation of granules and tablets active ingredient paracetamol ibuprofen and its evaluation results. Strada Journal of Pharmacy, 3(2), 53-57.https://doi.org/10.30994/sjp.v3i2.139
Zilhadia, Z., Amaliya, S., Anggraeni, Y., Anggia, V., & Harahap, Y. (2021). Preparation and Evaluation of Paracetamol Tablets Using Goatskin Gelatin as a New Binder. Research Square, 1.https://doi.org/10.21203/rs.3.rs-151247/v1.