The Effect Of Different Binder Types On The Results Of Hardness Evaluation Tests And Tablet Disintegration Time Using The Wet Granulation Method: Literature Review

Ananda Syalomita Kassang; Ameliana Fitria; Salwa Roihana; Muhammad Ni'am Maulana; Khafida Azida Ulil Khusna

doi:10.55227/ijhet.v5i4.856

Authors

Ananda Syalomita Kassang Pharmacy Study Program, Faculty of Medicine, Semarang State University
Ameliana Fitria Pharmacy Study Program, Faculty of Medicine, Semarang State University
Salwa Roihana Pharmacy Study Program, Faculty of Medicine, Semarang State University
Muhammad Ni'am Maulana Pharmacy Study Program, Faculty of Medicine, Semarang State University
Khafida Azida Ulil Khusna Pharmacy Study Program, Faculty of Medicine, Semarang State University

DOI:

https://doi.org/10.55227/ijhet.v5i4.856

Keywords:

tablets, binder, wet granulation, tablet hardness, disintegration time

Abstract

Tablets are a widely used pharmaceutical dosage form due to their stability, ease of use, and dosage accuracy. In tablet manufacturing, particularly using the wet granulation method, the use of binders is a critical factor influencing the tablet's physical properties, particularly hardness and disintegration time. Various types of binders, both natural and synthetic, such as polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), gelatin, starch, and sodium carboxymethylcellulose (CMC-Na), have different characteristics in forming bonds between particles. This literature review aims to analyze the effect of different binder types on tablet hardness and disintegration time test results. The method used was a literature review of various scientific journals related to tablet formulations with various binders. The results indicate that increasing binder concentration generally increases tablet hardness but can also prolong disintegration time. Synthetic binders such as HPMC and gelatin tend to produce tablets with high mechanical strength, while binders such as PVP and starch provide more moderate hardness with faster disintegration times. Thus, the selection of the type and concentration of binder must be adjusted to the formulation objectives to obtain an optimal balance between tablet hardness and disintegration time.

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References

Aanisah, N., Wardhana, Y. W., Chaerunisaa, A. Y., & Budiman, A. (2022). Review on modification of glucomannan as an excipient in solid dosage forms. Polymers, 14(13), 2550.

Abdullahi, A. K., Olowosulu, A. K., & Allagh, T. S. (2024). Preparation and evaluation of metronidazole tablets produced with different binders using wet granulation method. Malaysian Journal of Pharmaceutical Sciences, 22(1), 87–104.

Anindhita, M. A., Khasanah, K., Sajuri, S., Priharwanti, A., & Sulistyanto, I. (2022). Formulasi sediaan tablet hisap ekstrak daun glodokan tiang dengan CMC-Na sebagai bahan pengikat. Cendekia Journal of Pharmacy, 6(2), 1–10.

Asyiva, Hafifah, F. N., Agustina, L. S., Madhani, M. F., Latifah, N., Jannah, R., & Amalia, Y. R. (2024). REVIEW: Formulasi tablet metode granulasi basah dan evaluasi sifat fisik tablet. Sains Medisina, 3(2), 60–72.

Aulton, M. E., & Taylor, K. M. G. (2018). Aulton’s pharmaceutics: The design and manufacture of medicines (5th ed.). Elsevier.

Bahlmann, L., Finke, J. H., & Kwade, A. (2025). Process characterisation of continuous ring layer wet granulation at small scale. International Journal of Pharmaceutics: X, 10, Article 100454.

Buang, A., Adriana, A. N. I., & Rejeki, S. (2023). Formulasi tablet ekstrak etanol biji buah pinang (Areca catechu L.) dengan variasi konsentrasi gelatin sebagai bahan pengikat. Jurnal Mandala Pharmacon Indonesia, 9(1), 100-110.

Cahyani, A. N., Susanto, A., Dewi, I. R., & Nurhikmah, I. (2023). Formulasi tablet parasetamol dengan kombinasi PVP dan amilum umbi porang (Amorphophallus oncophyllus) sebagai bahan pengikat terhadap sifat fisik tablet. JOPHUS: Journal of Pharmacy UMUS, 4(2), 1–11.

de Koster, S. A. L., Pitt, K., Litster, J. D., & Smith, R. M. (2019). High-shear granulation: An investigation into the granule consolidation and layering mechanism. Powder Technology, 355, 514–525.

Devi, L. A. S., Shodiquna, Q. A., Eni, N. W. S. D., Arisanti, C. I. S., & Samirana, P. O. (2018). Optimasi konsentrasi polivinil pirolidon (PVP) sebagai bahan pengikat terhadap sifat fisik tablet ekstrak etanol rimpang bangle (Zingiber cassumunar Roxb). Jurnal Farmasi Udayana, 7(2), 45–52.

Dewi, S. P. P., Prasetia, I. G. N. J. A., & Arisanti, C. I. S. (2021). Pengaruh amilum manihot partially pregelatinized sebagai penghancur intragranular - ekstragranular pada formulasi tablet ekstrak daun ubi jalar merah (Ipomoea batatas L.). Jurnal Ilmiah Medicamento, 7(1), 62–70.

Fatma, I. D., Kartika, Y., Ulfah, R. R. M., Rinaldi, M. D., Pratama, R., & Pahlevi, M. R. (2024). Review: Formulasi dan evaluasi tablet pelepasan tertunda dan pelepasan terkontrol. Majalah Farmasetika, 9(5), 472–488.

Hadinugroho, W., Martodihardjo, S., Fudholi, A., & Riyanto, S. (2017). Evaluation of polymers as binder on coprocess of tablet. International Journal of ChemTech Research, 10(5), 46–51.

Hadisoewignyo, L., & Fudholi, A. (2016). Sediaan solida. Pustaka Pelajar.

Handayani, D. P., Sediawan, W. B., Timotius, D., & Puspitasari, M. (2023). Distribusi ukuran granul dari tepung singkong dengan tepung tapioka sebagai pengikat pada rotary drum granulator. Eksergi: Jurnal Ilmiah Teknik Kimia, 20(2), 52–57.

Hidayati, N., Meilany, N., & Andasari, S. D. (2020). Formulasi tablet kunyah asetosal dengan variasi konsentrasi PVP sebagai bahan pengikat. CERATA Jurnal Ilmu Farmasi, 11(1), 7–14.

Hu, Q., Huang, G., & Huang, H. (2025). Extraction, structure, activity and application of konjac glucomannan. Ultrasonics Sonochemistry, 116, 107315.

Jange, C. G., Wassgren, C. R., & Ambrose, K. (2023). The significance of tablet internal structure on disintegration and dissolution of immediate-release formulas: A review. Powders, 1(1), 1–19.

Kelana, A. S., Kusuma, A. P., & Indrati, O. (2018). Formulasi dan evaluasi tablet kaptopril menggunakan amilum umbi talas dan HPMC yang dimodifikasi sebagai pengisi dan pengikat metode kempa langsung. Eksakta: Jurnal Ilmu-ilmu MIPA, 18(1), 8-18.

Khabibah, N. A., & Ermawati, N. (2023). Formulasi dan evaluasi sediaan tablet dari ekstrak daun sirih hijau (Piper betle L.) dengan variasi konsentrasi bahan pengikat gelatin. Student Scientific Journal, 1(2), 163–170.

Kotamarthy, L., Karkala, S., Dan, A., Román-Ospino, A. D., & Ramachandran, R. (2024). Investigating the effects of mixing dynamics on twin-screw granule quality attributes via the development of a physics-based process map. Pharmaceutics, 16(4), 456.

Kusumo, N. N., & Mita, S. R. (2016). Review: Pengaruh natural binder pada hasil granulasi parasetamol. Farmaka, 14(1), 228–236.

Latifah, L., & Lukman, H. (2025). Formulasi dan karakterisasi tablet ekstrak daun sirih dengan variasi konsentrasi amilum Zea mays L. sebagai bahan penghancur. Pharmamedica Journal, 10(1), 123–130.

Lestari, A. B. S., & Eliana, R. (2025). Reworking potential of cassava starch as a binder in the production of paracetamol tablets using wet granulation method. Journal of Research in Pharmacy, 29(5), 1918–1929.

Maghfirah, S., Puteri, C. I. A., Dalimunthe, G. I., & Lubis, M. S. (2025). Formulation and evaluation of sustained-release tablets of Jatropha curcas L. leaf extract using HPMC and xanthan gum matrix for antihypertensive therapy. Indonesian Journal of Science and Pharmacy, 3(1), 15–21.

Muntaza, N. A., Nurjanah, P. M., & Endriyanto, N. C. (2025). Formulation and physical evaluation of Gnetum gnemon L. peel extract tablets using variation concentration of Na-CMC and starch 1500. BIS Health and Environmental Science, 2, Article 261.1-9.

Muthancheri, I., & Ramachandran, R. (2020). Mechanistic understanding of granule growth behavior in bi-component wet granulation processes with wettability differentials. Powder Technology, 367, 841–859.

Nareswari, T. L., Anandar, S. F., Putra, O. N., Sarmoko, & Adliani, N. (2024). Porang flour optimization as a natural tablet binder for bay leaf extract formulation. Acta Pharmaciae Indonesia: Acta Pharm Indo, 12(2), 15894.

Ningsih, D. R., Rahmawati, S., Putri, A., & Sari, D. (2020). Pengaruh hydroxypropyl methylcellulose terhadap sifat fisik tablet. Jurnal Farmasi.

Nurhaliza, S., Salim, N. L., Putri, A. N., Syahjiah, L., Dhaiffullah, M., & Latifah, N. (2024). Review artikel: Pengaruh penggunaan bahan pengikat alami dan sintetis pada kualitas fisik tablet. An-Najat, 2(4), 237–245.

Pratiwi, P. D., Citrariana, S., & Gemantari, B. M. (2023). Bahan tambahan dalam sediaan tablet: Review. Sinteza: Jurnal Farmasi Klinis dan Sains Bahan Alam, 3(2), 41–48.

Pratiwi, R. D., Murukmihadi, M., & Aisiyah, S. (2017). Pengaruh gelatin sebagai bahan pengikat terhadap sifat fisik tablet kunyah kelopak bunga rosella (Hibiscus sabdariffa L.). Pharmacy, 14(1), 31–40.

Rijal, M., Buang, A., & Prayitno, S. (2022). Pengaruh konsentrasi PVP K-30 sebagai bahan pengikat terhadap mutu fisik tablet ekstrak daun tekelan (Chromolaena odorata (L.). Jurnal Kesehatan Yamasi Makassar, 6(1), 98–111.

Safitri, R. Y., Bhagawan, W. S., & Primiani, C. N. (2024). Penggunaan polivinil pirolidon (PVP) sebagai bahan pengikat pada formula granul: Literatur review. PHARMADEMICA: Jurnal Kefarmasian dan Gizi, 4(1), 14–22.

Sairi, A., Rizky, H., Ariqah, M. P., Sumarno, N. N. I., Apriliana, R., & Latifah, N. (2024). Perbandingan pembuatan tablet dengan metode granulasi basah, kering, dan kempa langsung. Sains Medisina, 3(2), 36–39.

Sakinah, N., & Kurniawansyah, I. (2018). Karakteristik amilum sebagai bahan pengikat dalam formulasi tablet. Jurnal Farmasi Indonesia, 15(2), 123–130.

Sari, S. E. P., Aisyah, S., & Harjanti, R. (2024). OPTIMIZATION OF HPMC AND XANTHAN GUM AS MATRIX OF CAPTOPRIL SUSTAINED RELEASE TABLETS USING THE SIMPLEX LATTICE DESIGN (SLD) METHOD. Jurnal Farmasi & Sains Indonesia, 7(1), 162-171.

Setiawati, H., Buang, A., Rusli, R., Stevanu, H., & Dewi, R. (2021). Pemanfaatan pati singkong tergelatinasi sebagai pengikat tablet asetosal yang dibuat dengan metode kempa langsung. Media Farmasi Poltekkes Makassar, 16(2), 222–229.

Singha Roy, P., Biswas, A., Pratihar, S., & Ghosh, A. K. (2025). Effect of different binders on tablet hardness and disintegration time. International Journal of Pharmaceutical Research and Applications, 10(2), 1612–1620.

Siswanto, A., & Adibah, D. (2025). Pengaruh polimer HPMC K100M terhadap tablet floating ekstrak lidah buaya untuk terapi gastritis. PHARMACY: Jurnal Farmasi Indonesia, 22(2), 72–76.

Sugiyono, & Perwitosari, D. (2016). Pengaruh penggunaan tepung umbi porang (Amorphophallus oncophyllus) sebagai bahan pengikat terhadap sifat fisik dan kimia tablet parasetamol. Prosiding Seminar Nasional Sains dan Teknologi (SNST) ke-7, 16–20. Fakultas Teknik Universitas Wahid Hasyim Semarang.

Sun, Y., Xu, X., Zhang, Q., Zhang, D., Xie, X., Zhou, H., Wu, Z., Liu, R., & Pang, J. (2023). Review of konjac glucomannan structure, properties, gelation mechanism, and application in medical biology. Polymers, 15(8), 1852.

Suyono, E., & Nurhaini, R. (2016). Formulasi tablet ekstrak kunyit (Curcuma domestica Val.) dengan variasi bahan pengikat. Cerata Jurnal Ilmu Farmasi, 5(1), 1–16.

Thomas, N. A., Abdulkadir, W. S., Taupik, M., & Oktaviana, N. (2021). Pengaruh konsentrasi hydroxypropyl methylcellulose sebagai bahan pengikat pada sediaan tablet ekstrak rimpang jahe merah (Zingiber officinale Var. Rubrum). Indonesian Journal of Pharmaceutical Education, 1(3), 158–167.

United States Pharmacopeia. (2020). USP 43–NF 38. United States Pharmacopeial Convention.

Utami, A. S., Nawangsari, D., & Setianingsih, S. (2024). Effect of CMC-Na concentration as a binder in the formulation of chewable tablets of ethanol extract of onion tubers (Allium cepa L.). International Conference on Health and Biological Science (ICHBS), 247–264.

Wang, L. F., Wang, C. C., Huang, Y. D., Shen, L., Hong, Y. L., Zhao, L. J., & Lin, X. (2025). Research on the influences of binders on high shear wet granulation and tablet quality. Journal of Drug Delivery Science and Technology, 107, Artikel 106832.

Wijiani, N., Artemisia, S. D., Prasasti, A., Kustriyani, A., & Rohmah, S. U. (2025). Efek variasi konsentrasi CMC Na sebagai binder pada formulasi tablet hisap ekstrak kulit buah naga merah (Hylocereus polyrhizus). Jurnal Ilmiah Farmasi Akademi Farmasi, 8(1), 54-63.

Zaman, N. N., & Sopyan, I. (2020). Metode pembuatan dan kerusakan fisik sediaan tablet. Majalah Farmasetika, 5(2), 82–93.

Zilhadia, Z., Amaliya, S., Anggraeni, Y., Anggia, V., & Harahap, Y. (2021). Preparation and evaluation on paracetamol tablets using goatskin gelatin as a new binder. Research Square.