Coinfection Of Dengue Hemorrhagic Fever (DHF) Grade 1 And Typhoid Fever

Abstract

Coinfection of dengue hemorrhagic fever and typhoid fever is a clinical condition that is difficult to manage because both diseases share overlapping manifestations such as prolonged fever and gastrointestinal complaints. This case study aims to describe the clinical and laboratory profile and to evaluate the pharmacotherapy, including the identification of drug related problems, in a patient with coinfection of dengue hemorrhagic fever grade 1 and typhoid fever. The method used was a descriptive case study of one nineteen year old male patient treated at the Internal Medicine Ward of Arifin Achmad Regional General Hospital, Pekanbaru, from 19 to 23 September 2026, with data obtained from the medical record and assessed using the subjective, objective, assessment, and plan approach. The results showed a positive dengue NS1 antigen, reactive dengue IgG, nonreactive dengue IgM, and reactive Anti Salmonella IgM with a score of six, accompanied by thrombocytopenia reaching twenty five thousand per microliter and early leukopenia. The therapy was generally appropriate in indication and dosage, but the use of ketorolac in a thrombocytopenic dengue patient was identified as a drug related problem. In conclusion, the coinfection was confirmed clinically and serologically, and the pharmacist plays an essential role in identifying the bleeding risk and recommending paracetamol as the safer analgesic.