Antioxidant Body Lotion Formulation From Yakon Leaf Extract (Smallanthus Sonchifolius)
DOI:
https://doi.org/10.55227/ijhet.v4i6.659Keywords:
Antioxidant Activity, Body Lotion, DPPH Method, Smallanthus sonchifolius, Yakon LeavesAbstract
Free radicals due to UV exposure, pollution, and the environment damage the skin and accelerate premature aging, so natural antioxidants are needed. This study aims to formulate and evaluate antioxidant body lotion from ethanol extract of yacon leaves (Smallanthus sonchifolius). Semi-quantitative laboratory experimental research used old yacon leaves from Wonosobo as a purposive sample (1,897 g of dried simplicia). Instruments include a UV-Vis spectrophotometer for DPPH (515 nm) test, a Brookfield viscometer, and a pH meter. Data analysis used IC₅₀ regression and physical quality standards (SNI). The results showed that the IC₅₀ of the extract was 28.08 ppm (very strong, <50 ppm), positive phytochemical screening (phenolics, flavonoids), and all lotion formulas (F0-F3: 0-10% extract) met physical standards (pH 4.6-6.2, viscosity 2,187-9,230 cps, O/W emulsion). Formula F1 (2.5%) was optimal overall. The conclusion is that yacon leaf extract has strong potential for the development of a stable body lotion.
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Aljanah, FW, Oktavia, S., & Noviyanto, F. (2022). Formulation and evaluation of hand body lotion preparations from ethanol extract of watermelon leaves (Citrullus lanatus) as an antioxidant. Journal of Pharmacy, 1(5), 799–818.
Apriani, D., et al. (2023). The effect of extract concentration on the stability and viscosity of topical preparations. Scientific Journal of Pharmacy, 12(2), 45–53.
Chandra, D., & Rahmah. (2022). Physicochemical test of emulsion, gel, and emulgel preparations of goji berry (Lycium barbarum L.) ethanol extract. Indonesian Journal of Pharmacy, 11(2), 219–228.
Creswell, J. W., & Creswell, J. D. (2023). Research design: Qualitative, quantitative, and mixed methods approaches (6th ed.). Sage Publications.
Dewi, NP, & Putri, RA (2023). Phytochemical screening and biological activity of alkaloid compounds in herbal plants. Indonesian Journal of Pharmacy and Pharmaceutical Sciences, 10(2), 112–119.
Elawati, N., & Yuanita, L. (2021). Review: Pharmacological effects and toxic effects of yacon leaves (Smallanthus sonchifolius). Journal of Pharmaceutical Science and Community, 10(2), 135–146.
Emzir. (2022). Educational research methodology: Quantitative and qualitative. Rajawali Pers.
Faruki, RF (2021). Formulation and antioxidant activity test of ethanol extract of binahong (Anredera cordifolia) leaf cream using the DPPH method. Journal of Pharmacy, 8(1), 15–23.
Fatmawati, A., Ariskha, G., Dewi, APR, Rahman, IR, & Yanuarto, T. (2023). Formulation and stability test of emulgel from ethanol extract of butterfly pea flower (Clitoria ternatea L.) as lotion. Journal of Pharmacy and Applied Science, 6(2), 616–625.
Fatwami, EF, & Royani, S. (2023). Phytochemical screening and antioxidant testing of cayenne pepper (Capsicum frutescens L.) leaf extract. Scientific Journal of Pharmacy, 5, 253–260.
Handayani, R., Qamariah, N., Sartika, F., & Nugroho, SA (2024). Non-specific parameter test of ant nest tubers. Indonesian Pharmaceutical Journal, 7(2), 116–124.
Handayani, D., & Sutrisno. (2024). Identification of steroids and terpenoids in medicinal plant extracts using the Liebermann–Burchard method. Journal of Applied Chemistry, 9(1), 55–62.
Kurniati, E. (2022). The mechanism of antioxidant activity of flavonoid compounds in counteracting free radicals. Journal of Chemical Science, 4(2), 89–97.
Kusumawati, VH, Permatasari, DI, & Permata, BR (2023). Antioxidant test of extract and sunscreen cream formulation of white pomegranate (Punica granatum L.) peel using DPPH method and determination of SPF value. Journal of Pharmacy, 10(1), 1–10.
Lestari, D., & Sari, M. (2024). Identification of phenolic compounds using the FeCl₃ method and their contribution to antioxidant activity. Journal of Pharmaceutical Chemistry, 8(1), 22–30.
Maula, ADR, Fauziah, DT, Purwanti, A., & Agustin, AT (2025). Formulation and evaluation of hand body lotion preparations from avocado seed extract (Persea americana Mill.). Journal of Pharmacy and Preparation Technology, 3(1), 11–22.https://doi.org/10.70608/6hahad10
Maulida, Z. (2020). Phytochemical screening of secondary metabolite compounds of ethanol extract of life-connecting leaves (Gynura procumbens). Journal of Herbal Pharmacy, 5(1), 1–8.
Manoj, M., Nayak, M., Hanumantharaju, Premananthan, P., & Shincy. (2025). A study on drying methods for medicinal plants. Journal of Advance and Future Research, 3(6), 221–233.
Mufidah, Rohama, & Hidayah, N. (2025). Determination of flavonoid content of bidara leaf extract (Ziziphus spina-christi) using UV-Vis spectrophotometry method. Journal of Pharmaceutical Science, 17(2), 145–152.
Nagalievska, M., et al. (2025). Oxidative stress and skin aging: Mechanisms and protective strategies. Journal of Dermatological Science, 110(1), 45–53.
Narulita, A., Fadel, MN, & Besan, EJ (2025). Antibacterial activity and physical characteristics test of clay mask of parijoto fruit extract (Medinilla speciosa) against Staphylococcus aureus. Journal of Pharmacy and Cosmetics, 5(3), 273–286.
Nugraha, AT, Firmansyah, MS, & Jumaryatno, P. (2017). Compound profile and antioxidant activity of yakon leaves (Smallanthus sonchifolius) using DPPH and CUPRAC methods. Journal of Pharmaceutical Chemistry, 13(1), 14–20.
Nugroho, A., Prasetyo, B., & Lestari, S. (2025). Antioxidant activity of flavonoids from medicinal plant extracts using the reduction method. Journal of Chemical Science and Applications, 28(1), 1–8.
Nurheni, A., Septiani, AR, Srifitriani, E., Fatmawati, F., Haryadi, R., Azzahra, SK, Lustianah, T., & Yuniarsih, N. (2023). Serum from various natural ingredients that have potential as antioxidants. Ilmiah Wahana Pendidikan, 9(September), 34–40.
Puentes, N.C., & Amador, A.A. (2020). Hypoglycaemic properties of yacon (Smallanthus sonchifolius): A review. Journal of Medicinal Plants Research, 14(6), 1–8.
Ramdhini, RN (2023). Standardization of the quality of simplicia and ethanol extract of butterfly pea flowers (Clitoria ternatea L.). Indonesian Journal of Pharmacy, 13(1), 32–38.
Rawal, S., et al. (2025). Environmental pollutants and skin oxidative damage: Emerging concerns. International Journal of Cosmetic Science, 47(2), 150–160.
Riwanti, P., Izazih, F., & Amaliyah. (2020). The effect of different ethanol concentrations on the total flavonoid content of Sargassum polycystum extract. Journal of Pharmaceutical Science, 2(2), 82–95.
Saputri, AD, Sa'ad, M., Maharani, P., & Prahesti, MT (2024). The effect of extraction methods and solvents on the secondary metabolite content and antioxidant activity of insulin leaf extract (Smallanthus sonchifolius). Lampung Pharmaceutical Journal, 13(2).https://doi.org/10.37090/jfl.v13i2.1629
Sari, M., & Yuliana, T. (2023). The role of saponins in biological activity and stability of herbal formulations. Journal of Natural Materials Technology, 7(2), 75–82.
Sudaryono. (2021). Quantitative, qualitative, and mixed method research methodology. Rajawali Pers.
Sugiyono. (2021). Quantitative, qualitative, and R&D research methods. Alfabeta.
Suryani, A., & Wahyuni, T. (2025). Formulation of hand & body lotion with tomato seed oil (Solanum lycopersicum L.): An innovative study of moisturizer and antioxidant for skin care. Indonesian Journal of Medical and Pharmaceutical Science.
Tambunan, IJ, & Julianty, SM (2025). Formulation and antioxidant activity test of body lotion preparation of ethanol extract of mustard greens (Cyanthillium cinereum) leaves as a moisturizer. Journal of Pharmacy and Cosmetics, 5(2), 187–194.
Telaumbanua, PTK, Sudewi, & Febriani, Y. (2024). Formulation and antioxidant testing of body lotion preparation of ethanol extract of menteng leaves (Baccaurea racemosa) as a skin moisturizer. Jambura Journal of Health Science and Research, 1, 13–22.
Tivani, I., Amananti, W., Putri, AR, & Bersama, PH (2021). Antibacterial activity test of handwash extract of turi (Sesbania grandiflora) leaves against Staphylococcus aureus. Journal of Clinical Pharmacy, 7(1), 86–91.
Wandira, A., et al. (2023). Analysis of water content testing of various natural ingredient simplicia using the gravimetric method. Journal of Herbal Pharmacy, 9(September), 190–193.
Widiasriani, IAP, et al. (2024). The role of flavonoid antioxidants in inhibiting free radicals. Journal of Pharmacy and Health Sciences, 6, 188–197.
Widyastuti, AI, & Suryanti, D. (2023). Formulation and evaluation of nanoemulsion preparations of garlic bulb extract (Allium sativum L.). Journal of Applied Pharmacy, 5(2), 178–185.
Wijayanti, NPP, Hendriati, L., Hamid, IS, Widodo, T., & Kuncorojakti, S. (2023). Effectiveness of transdermal patch of insulin leaf (Smallanthus sonchifolius) ethanol extract on blood glucose levels in white rats. Journal of Pharmaceutical Science and Clinical Research, 8(2), 152–164.https://doi.org/10.20961/jpscr.v8i2.59508
Zulfa, E., Novianto, D., & Setiawan, D. (2019). Formulation of diclofenac sodium nanoemulsion with variations in the combination of Tween 80 and Span 80. Indonesian Pharmaceutical Media, 14(1), 1471–1477.
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